Title :
Analysis of drug sensitivity of ventricular myocardial ionic channels based on the global bifurcation structure
Author :
Nagata, Sayaka ; DOI, Shinji ; Kumagai, Sadatoshi
Author_Institution :
Dept. of Electr. Eng., Osaka Univ., Japan
Abstract :
The global bifurcation structure of the Hodgkin-Huxley-type equation of a ventricular myocardial cell is analyzed by varying the maximum conductances of ionic channels as a bifurcation parameter. From the results, we investigate the drug sensitivity of various ionic channels of a ventricular myocardial cell.
Keywords :
bifurcation; biomembrane transport; cardiology; drugs; nonlinear differential equations; Hodgkin-Huxley type equation; bifurcation structure; biomembrane transport; drug sensitivity analysis; ventricular myocardial cell; ventricular myocardial ionic channels; Bifurcation; Biomembranes; Cardiac disease; Cells (biology); Differential equations; Drugs; Heart; Intersymbol interference; Myocardium; Nonlinear equations;
Conference_Titel :
Circuits and Systems, 2004. MWSCAS '04. The 2004 47th Midwest Symposium on
Print_ISBN :
0-7803-8346-X
DOI :
10.1109/MWSCAS.2004.1354010
