Title :
Functional magnetic nanoparticles for circulating tumor cells screening in integrated microfluidic system
Author :
Jiao Wu ; Yaling Li ; Kun Qian ; Xiaojing Zhang ; Ting Shen
Author_Institution :
Center for Bio-Nano-Chips & Diagnostics in Translational Med., Shanghai Jiao Tong Univ., Shanghai, China
Abstract :
Screening and analysis of circulating tumor cells (CTCs) can potentially provide crucial information for clinical prevention, diagnosis and treatment of cancer metastasis. Herein we designed various functional magnetic nanoparticles (NPs) to capture CTCs, with further optimization towards rare cell separation with high specificity from the whole blood. In Vitro characterizations were carried out using an integrated microfluidic system coupled with the immunomagnetic assays on-chip towards efficient screening of CTCs in blood samples with high sensitivity.
Keywords :
bioMEMS; biomedical equipment; blood; cancer; cellular biophysics; magnetic particles; microfluidics; nanomagnetics; nanomedicine; nanoparticles; patient diagnosis; patient treatment; tumours; CTC screening; cancer metastasis diagnosis; cancer metastasis treatment; cell separation; circulating tumor cell analysis; circulating tumor cell screening; functional magnetic nanoparticles; immunomagnetic assay on-chip; in vitro characterizations; integrated microfluidic system; whole blood samples; Blood; Cancer; Magnetic particles; Magnetic resonance imaging; Magnetic separation; Microfluidics; Tumors; cell separation; circulating tumor cells (CTCs); immunomagnetic assay; integrated microfluidic system; magnetic nanoparticles;
Conference_Titel :
Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), 2014 International Conference on
DOI :
10.1109/3M-NANO.2014.7057335
