• DocumentCode
    3585145
  • Title

    Fully IC Label-Free Aptasensor with Interdigitated Microelectrodes in Microfluidic Channel

  • Author

    Tashtoush, Abdullah

  • Author_Institution
    Biomed. Syst. & Inf. Eng. Dept., Yarmouk Univ., Irbid, Jordan
  • fYear
    2014
  • Firstpage
    124
  • Lastpage
    127
  • Abstract
    So far, DNA microarrays are known as a surface on which sequences from thousands of different genes are covalently attached to fixed probes. By using DNA microarrays technology, it allows a parallel analysis for the selective nature of DNA-DNA or DNA-RNA hybridization, simultaneously. DNA microarrays require optically active labels attached to the target DNA and fluorescence sensing. Some pioneering Aptasensor are one type of DNA microarrays technology, which employs electrochemical labels, redox-active molecules or enzymes, which produces an electrical current through conductive electrodes in case of complementary sequences. DNA microarrays allow highly parallel and low cost analysis. In fact, they take advantage of the capability to fabricate a large number of miniaturized detection sites on a substrate to extract information after exposition to the target DNA to be detected or recognized.
  • Keywords
    DNA; RNA; bioMEMS; biochemistry; biological techniques; biosensors; bonds (chemical); electrochemical electrodes; electrochemical sensors; enzymes; fluorescence; genetics; integrated circuits; lab-on-a-chip; microchannel flow; microelectrodes; molecular biophysics; molecular configurations; oxidation; reduction (chemical); sequences; DNA microarray technology; DNA-DNA hybridization; DNA-RNA hybridization; complementary sequence; conductive electrode; covalently attachment; electrical current production; electrochemical label; enzyme; fixed probe; fluorescence sensing; fully IC label-free aptasensor; gene sequence; interdigitated microelectrode; low cost analysis; microfluidic channel; miniaturized detection site fabrication; optically active label attachment; parallel analysis; pioneering aptasensor; redox-active molecule; selectivity; simultaneous analysis; substrate; target DNA attachment; target DNA detection; target DNA recognition; Biomedical optical imaging; Biosensors; CMOS integrated circuits; DNA; Electrodes; Optical device fabrication; Optical sensors; Aptasensor; DNA; EIS; IDMA; MLoC; WEC; WEG;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Modelling Symposium (AMS), 2014 8th Asia
  • Print_ISBN
    978-1-4799-6486-4
  • Type

    conf

  • DOI
    10.1109/AMS.2014.33
  • Filename
    7079286