DocumentCode
3585145
Title
Fully IC Label-Free Aptasensor with Interdigitated Microelectrodes in Microfluidic Channel
Author
Tashtoush, Abdullah
Author_Institution
Biomed. Syst. & Inf. Eng. Dept., Yarmouk Univ., Irbid, Jordan
fYear
2014
Firstpage
124
Lastpage
127
Abstract
So far, DNA microarrays are known as a surface on which sequences from thousands of different genes are covalently attached to fixed probes. By using DNA microarrays technology, it allows a parallel analysis for the selective nature of DNA-DNA or DNA-RNA hybridization, simultaneously. DNA microarrays require optically active labels attached to the target DNA and fluorescence sensing. Some pioneering Aptasensor are one type of DNA microarrays technology, which employs electrochemical labels, redox-active molecules or enzymes, which produces an electrical current through conductive electrodes in case of complementary sequences. DNA microarrays allow highly parallel and low cost analysis. In fact, they take advantage of the capability to fabricate a large number of miniaturized detection sites on a substrate to extract information after exposition to the target DNA to be detected or recognized.
Keywords
DNA; RNA; bioMEMS; biochemistry; biological techniques; biosensors; bonds (chemical); electrochemical electrodes; electrochemical sensors; enzymes; fluorescence; genetics; integrated circuits; lab-on-a-chip; microchannel flow; microelectrodes; molecular biophysics; molecular configurations; oxidation; reduction (chemical); sequences; DNA microarray technology; DNA-DNA hybridization; DNA-RNA hybridization; complementary sequence; conductive electrode; covalently attachment; electrical current production; electrochemical label; enzyme; fixed probe; fluorescence sensing; fully IC label-free aptasensor; gene sequence; interdigitated microelectrode; low cost analysis; microfluidic channel; miniaturized detection site fabrication; optically active label attachment; parallel analysis; pioneering aptasensor; redox-active molecule; selectivity; simultaneous analysis; substrate; target DNA attachment; target DNA detection; target DNA recognition; Biomedical optical imaging; Biosensors; CMOS integrated circuits; DNA; Electrodes; Optical device fabrication; Optical sensors; Aptasensor; DNA; EIS; IDMA; MLoC; WEC; WEG;
fLanguage
English
Publisher
ieee
Conference_Titel
Modelling Symposium (AMS), 2014 8th Asia
Print_ISBN
978-1-4799-6486-4
Type
conf
DOI
10.1109/AMS.2014.33
Filename
7079286
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