Title :
Modeling low frequency cardiorespiratory interaction using broadband hypoxic stimulation
Author :
Mullick, Sachin ; Bruce, Eugene ; Cross, Andrew ; Patwardhan, Abhijit
Author_Institution :
Center for Biomed. Eng., Kentucky Univ., Lexington, KY, USA
Abstract :
The authors investigated cardiorespiratory dynamic interaction within the low frequency region (<0.15 Hz) using broadband hypoxic stimulation during mean inspired oxygen levels of 16.5% and 12.5%. Spectral broadening of O2 level was obtained by pseudo random binary switching (PRBS) of inspired O2 level between 21% O 2 and 4% (12% for mild hypoxia), balance nitrogen. Coherence analysis showed that during moderate hyponia, responses of R-R interval, BP and ventilation were statistically related. Partial coherences showed fluctuations in R-R interval and ventilation were correlated in the low frequency region. Parametric modeling resulted in a model with four poles and two zeros as a best fit between F1O2 and R-R interval
Keywords :
cardiology; haemodynamics; oxygen; physiological models; pneumodynamics; poles and zeros; 0.15 Hz; N2; O2; R-R interval; broadband hypoxic stimulation; inspired O2 level; low frequency cardiorespiratory interaction modeling; mild hypoxia; moderate hyponia; parametric modeling; pseudo random binary switching; spectral broadening; ventilation; Autonomic nervous system; Cardiology; Feedback loop; Fluctuations; Frequency; Gases; Heart rate; Heart rate variability; Nitrogen; Ventilation;
Conference_Titel :
Biomedical Engineering Conference, 1997., Proceedings of the 1997 Sixteenth Southern
Print_ISBN :
0-7803-3869-3
DOI :
10.1109/SBEC.1997.583320
