Title :
Dendritic cell vaccination for glioblastoma multiforme: Clinical experience and future directions
Author :
Dejaegher, Joost ; Solie, Lien ; De Vleeschouwer, Steven ; Van Gool, Stefaan W.
Author_Institution :
Dept. of Neurosciences, KU Leuven, Leuven, Belgium
Abstract :
Dendritic cell vaccination is an experimental treatment for malignant gliomas, and has been subject of a translational program for more than ten years in our center. In vitro research, animal models and clinical trials for relapsed and newly diagnosed patients have been conducted. In this paper, we give an overview of the mechanism and rationale of this treatment for brain cancer. We also briefly discuss recently updated results of our clinical trials. Finally, we mention strategies to select patients for this therapy and additional immunotherapeutic strategies to further enhance the antitumor immune responses.
Keywords :
brain; cancer; cellular biophysics; patient treatment; reviews; animal models; antitumor immune responses; brain cancer; clinical experience; clinical trials; dendritic cell vaccination; experimental treatment; future directions; glioblastoma multiforme; immunotherapeutic strategies; in vitro research; malignant gliomas; newly diagnosed patients; relapsed patients; translational program; Electronic mail; Immune system; Neurosurgery; Standards;
Conference_Titel :
In Silico Oncology and Cancer Investigation (IARWISOCI), 2014 6th International Advanced Research Workshop on
DOI :
10.1109/IARWISOCI.2014.7034631
