Title :
Simulating tumour vasculature at multiple scales
Author :
Grogan, J.A. ; Maini, P.K. ; Pitt-Francis, J. ; Byrne, H.M.
Author_Institution :
Wolfson Centre for Mathermatical Biol. (WCMB), Univ. of Oxford, Oxford, UK
Abstract :
The vasculature plays an important role in tumour development and treatment, acting as a conduit for nutrients, waste products and therapeutics. Simulating transport and network structure evolution in malformed tumour networks is a challenging multi-scale problem. Current approaches for modelling the vasculature at distinct size scales are described here, followed by a discussion of current efforts in developing integrated multi-scale modelling approaches for simulating the growth and treatment of vascular tumours.
Keywords :
biochemistry; biomechanics; biotransport; blood vessels; drugs; patient treatment; physiological models; tumours; integrated multiscale modelling; malformed tumour network; multiple scale tumour vasculature simulation; multiscale problem; network structure evolution simulation; nutrient conduit; therapeutics conduit; transport simulation; tumour development; vascular tumour growth simulation; vascular tumour treatment simulation; vasculature modelling; vasculature size scale; waste product conduit; Biological system modeling; Cancer; Computational modeling; Ice; Logic gates; Predictive models;
Conference_Titel :
In Silico Oncology and Cancer Investigation (IARWISOCI), 2014 6th International Advanced Research Workshop on
DOI :
10.1109/IARWISOCI.2014.7034633
