DocumentCode :
3613111
Title :
A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction
Author :
Kuo, Po-Hung ; Kuo, Jui-Chang ; Hsueh, Hsiao-Ting ; Hsieh, Jian-Yu ; Huang, Yi-Chun ; Wang, Tao ; Lin, Yen-Hung ; Lin, Chih-Ting ; Yang, Yao-Joe ; Lu, Shey-Shi
Author_Institution :
Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan
Volume :
9
Issue :
6
fYear :
2015
Firstpage :
790
Lastpage :
800
Abstract :
A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 
m CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, magnetic flushing and threshold detection based on Hall sensor array readout analysis. To verify the function of this chip, in-vitro Tumor necrosis factor- 
(TNF- ) and N-terminal pro-brain natriuretic peptide (NT-proBNP) tests are performed by this 9 mm 
-sized single chip. The cost, efficiency and portability are considerably improved compared to the prior art.
Keywords :
Biosensors; Blood; CMOS integrated circuits; Lab-on-a-chip; System-on-chip; Biosensor; CMOS; lab-on-a-chip; magnetic bead; rapid blood test;
fLanguage :
English
Journal_Title :
Biomedical Circuits and Systems, IEEE Transactions on
Publisher :
ieee
ISSN :
1932-4545
Type :
jour
DOI :
10.1109/TBCAS.2015.2507618
Filename :
7386717
Link To Document :
