Closed loop glucose control in critical care patients: Previous study for clinical essays

The feasibility of the design of a closed loop system to control glucose levels in critical care patients is presented in this paper. Considering the basic elements for its construction: The plasma glucose detection using a subcutaneous sensor and a Kalman filter, the model of glucose metabolism, and having special consideration in the method to calculate the optimal insulin infusion designing classical control schemes (PID and PI) and a GPC (predictive controller).