Changes in bone components of newborn rats after maternal treatment with cytarabine

Author

Zofia Drzazga;Katarzyna Michalik;Michal Kaszuba;Hanna Trzeciak

Author_Institution

A. Che?kowski Institute of Physics, Department of Medical Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice, Poland

fYear

2008

Firstpage

1

Lastpage

5

Abstract

Concentration of abundant elements like calcium as well as elements present in trace amount like zinc, iron, silicon, potassium in mandibles of 7, 14 an 28 day old newborn rats after maternal administration with cytarabine were determined by X-ray fluorescence analysis. The studies were carried out using measurement system containing X-ray tube ECLIPSE-III and X-ray and gamma ray detector XR-lOOT-CdTe (Amptek Inc.). Concentrations of studied elements (Ca, Zn, Si, K, Fe) obtained for bones from cytarabine treated rats (3 mg/kg sc.) markedly differ from those obtained for bones from control group. Cytarabine administration during pregnancy disrupts bone ontogenesis and mineralization of new born rats. Remarkable changes in Ca, Si and Fe content strived for concentration level compared with this characteristic for the control group with time.

Keywords

"Bones","Pediatrics","Rats","Calcium","Iron","Zinc","Silicon","Fluorescence","Gamma ray detectors","Pregnancy"

Publisher

ieee

Conference_Titel

BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on

Print_ISBN

978-1-4244-2844-1

Type

conf

DOI

10.1109/BIBE.2008.4696763

Filename

4696763