Title :
Acrylic star block copolymers as hydrophobic drug carriers
Author :
Gozde Genc;Aysegul Batigun;Oguz Bayraktar;Ozcan Altintas;Umit Tunca;Gurkan Hizal
Author_Institution :
Kimya M?hendisli?i B?l?m?, ?zmir Y?ksek Teknoloji Enstit?s?, Turkey
fDate :
5/1/2009 12:00:00 AM
Abstract :
Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by atomic transfer radical polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.
Keywords :
"Drugs","Polymers","Atomic measurements","Arm","Fluorescence","Spectroscopy","Load modeling","Biodegradable materials"
Conference_Titel :
Biomedical Engineering Meeting, 2009. BIYOMUT 2009. 14th National
Print_ISBN :
978-1-4244-3605-7
DOI :
10.1109/BIYOMUT.2009.5130339
