A weighted patient specific electromechanical model of the heart

This paper presents a patient specific deformable heart model that involves the known electric and mechanic properties of the cardiac cells and tissue. The accuracy and efficiency of the algorithm was tested for anisotropic and inhomogeneous 3D domains using ten Tusscher´s and Nygen´s cardiac cell models. During propagation of depolarization wave, the kinetic, compositional and rotational anisotropy is included in the tissue, organ and torso model. The applied patient specific parameters were determined by an evolutionary computation method. An intensive parameter reduction was performed using the abstract formulation of the searching space. This patient specific parameter representation enables the adjustment of deformable model parameters in real-time. The validation process was performed using measured ECG and ultrasound image records that were compared with simulated signals and shapes using an abstract, parameterized evaluation criterion.