Signal source localization with tetrodes: Experimental verification

Multi-sensor electrodes for extracellular recording of neuronal action potentials have significantly increased the signal-to-noise ratio (SNR) in neurophysiological experiments, ultimately leading to a more accurate interpretation of scientific data. Apart from improving SNR, we hypothesize that these electrodes can be used to estimate the location of underlying neuronal signal sources, and perhaps other parameters such as the size and shape of neurons whose activities are being recorded. This study introduces the multiple signal classification (MUSIC) algorithm to the problem of neuron localization and presents the first experimental demonstration of signal source localization using commercially available 4-sensor electrodes (tetrodes).