DocumentCode :
3650825
Title :
Silicon Nanotweezers with a microfluidic cavity for the real time characterization of DNA damage under therapeutic radiation beams
Author :
Grégoire Perret;Po-Tsun Chiang;Thomas Lacornerie;Momoko Kumemura;Nicolas Lafitte;Herve Guillou;Laurent Jalabert;Eric Lartigau;Teruo Fujii;Fabrizio Cleri;Hiroyuki Fujita;Dominique Collard
Author_Institution :
LIMMS/CNRS-IIS, UMI-2820, University of Tokyo, Japan
fYear :
2013
fDate :
7/1/2013 12:00:00 AM
Firstpage :
6820
Lastpage :
6820
Abstract :
We report the biomechanical characterization of λ-DNA bundle exposed to a therapeutic radiation beam by silicon Nanotweezers. The micromechanical device endures the harsh environment of radiation beams, and still retains molecular-level detection accuracy. The real-time DNA bundle degradation is observed in terms of biomechanical stiffness and viscosity reduction, both in air and in solution. These results pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.
Keywords :
"DNA","Silicon","Microfluidics","Cavity resonators","Degradation","Radiation effects","Real-time systems"
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
ISSN :
1094-687X
Electronic_ISBN :
1558-4615
Type :
conf
DOI :
10.1109/EMBC.2013.6611123
Filename :
6611123
Link To Document :
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