Title :
Silicon Nanotweezers with a microfluidic cavity for the real time characterization of DNA damage under therapeutic radiation beams
Author :
Grégoire Perret;Po-Tsun Chiang;Thomas Lacornerie;Momoko Kumemura;Nicolas Lafitte;Herve Guillou;Laurent Jalabert;Eric Lartigau;Teruo Fujii;Fabrizio Cleri;Hiroyuki Fujita;Dominique Collard
Author_Institution :
LIMMS/CNRS-IIS, UMI-2820, University of Tokyo, Japan
fDate :
7/1/2013 12:00:00 AM
Abstract :
We report the biomechanical characterization of λ-DNA bundle exposed to a therapeutic radiation beam by silicon Nanotweezers. The micromechanical device endures the harsh environment of radiation beams, and still retains molecular-level detection accuracy. The real-time DNA bundle degradation is observed in terms of biomechanical stiffness and viscosity reduction, both in air and in solution. These results pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.
Keywords :
"DNA","Silicon","Microfluidics","Cavity resonators","Degradation","Radiation effects","Real-time systems"
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Electronic_ISBN :
1558-4615
DOI :
10.1109/EMBC.2013.6611123