Semi-automatic Compartment Extraction to Assess 3D Bone Mineral Density and Morphometric Parameters of the Subchondral Bone in the Tibial Knee

We present a new semi-automatic method to extract the bone mineral density (BMD) and bone proportion (BV/TV)with the aim to analyze subchondral bone changes due to knee osteoarthritis in clinically relevant compartments (medial versus lateral) and (anterior versus posterior). This method based on convex hull is developed initially on high resolution peripheral computed tomography but can potentially be applied in clinical CT with sufficient resolution.