Non-rigid registration with constraint of anatomical landmarks for assessment of locoregional therapy

Locoregional therapy (LT) is a popular method to cure hepatocellular carcinoma (HCC) of liver in the last few years. Evaluating the treated margin is a critical factor for predicting local recurrence after locoregional treatment is done. In this paper, we proposed a non-rigid registration method with constraint of anatomic landmarks for assessing treated margin of locoregional therapy. Compared with conventional non-rigid registration, which uses only mutual information as cost function (without any constraints of anatomical structure), our proposed method can achieve high registration accuracy not only for shape warping, but also for internal anatomic structure. The effectiveness of our proposed method has been demonstrated with clinical date set.