Single ion channel CMOS electrochemical instrument for high throughput recording arrays

This paper presents instrumentations for high throughput single ion channel recording array used for proteomics. The instrumentations incorporates two-stage amplifier using shared operational transconductance amplifier structure. The proposed sensor frontend reduces power consumption and area of circuit without any performance degradations in terms of bandwidth and noise. Two compact, low noise, low power circuits are introduced to address the proposed amplifier structure. As a results, over 400 ion channels are implemented on a single chip. Design #1 is suitable for recording ion currents as low as 20pA within 9kHz bandwidth using minimal power. Design #2 is able to sense input currents as low as 10pA within a maximum bandwidth of 100kHz.