Electrical detection of single particle in cylindrical solid-state nanopores

This paper presented a new technique for electrical detection of single nanoparticle in a cylindrical solid-state nanopore by measuring the blockage ionic current change. Both numerical and analytical models were developed to simulate and optimize the electrical responses of the device when a single particle was passing through the nanopore. The effects of different nanopore geometries on nanoparticle detection performance were discussed, which could provide guidelines for the device fabrications and nanoparticle detection applications.