Correlation study on DWI manifestation, ADC value and serum NSE level in neonates with hypoxia-ischemic encephalopathy

Objective: To study the relationship between neonatal hypoxic-ischemic encephalopathy (HIE) lesions´ images in DWI, the ADC value and serum NSE, in order to improve the basis for the early diagnosis and treatment of HIE. Methods: To detect serum NSE of 27 cases of HIE patients and adept MRI examination in one week, and measure the ADC value of the lesion. 30 healthy newborns were collected randomly as control group. Results: The ADC value of the lesions in normal neonatal was higher than that in HIE patients (P<;0.05). There were no significant difference between mild and moderate HIE patient´s ADC value (P>0.05). The ADC value of the severe HIE patients was lower than that in mild and moderate patients (P<;0.05). The serum NSE value of severe HIE patients was higher than that of mild and moderate patients. The serum NSE of moderate HIE patients was higher than that of mild patients (P<;0.05). The high signal lesions of DWI images in severe HIE patients were more than mild and moderate patients, and moderate HIE patients were more than mild patients (P<;0.05). Conclusions: The ADC value of the lesions in HIE patients was decreased compared to the control group, and it was negatively correlated with the serum NSE level, and we can combine ADC values with serum NSE level to provide a new theory basis for the early diagnosis and treatment of HIE patients.