• DocumentCode
    3684063
  • Title

    Deep tissue targeted near-infrared optogenetic stimulation using fully implantable upconverting light bulbs

  • Author

    Maysamreza Chamanzar;David J. Garfield;Jillian Iafrati;Vikaas Sohal;Emory Chan;Bruce Cohen;P. James Schuck;Michel M. Maharbiz

  • Author_Institution
    University of California Berkeley, USA
  • fYear
    2015
  • Firstpage
    821
  • Lastpage
    824
  • Abstract
    We demonstrate for the first time, the possibility of targeted optogenetic stimulation of neurons deep into brain tissue (>2 mm) in a minimally-invasive way by sending near-infrared light through tissue to excite passive lanthanide-doped blue-emitting upconverting nanocrystals (UCNPs) encapsulated in Parylene C microstructure light bulbs that emit visible (blue) light and locally excite opsins with high spatial resolution.
  • Keywords
    "Brain","Mice","Neurons","Absorption","Glass","Microscopy","Nanocrystals"
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE
  • ISSN
    1094-687X
  • Electronic_ISBN
    1558-4615
  • Type

    conf

  • DOI
    10.1109/EMBC.2015.7318488
  • Filename
    7318488
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3684063