Title :
Deep tissue targeted near-infrared optogenetic stimulation using fully implantable upconverting light bulbs
Author :
Maysamreza Chamanzar;David J. Garfield;Jillian Iafrati;Vikaas Sohal;Emory Chan;Bruce Cohen;P. James Schuck;Michel M. Maharbiz
Author_Institution :
University of California Berkeley, USA
Abstract :
We demonstrate for the first time, the possibility of targeted optogenetic stimulation of neurons deep into brain tissue (>2 mm) in a minimally-invasive way by sending near-infrared light through tissue to excite passive lanthanide-doped blue-emitting upconverting nanocrystals (UCNPs) encapsulated in Parylene C microstructure light bulbs that emit visible (blue) light and locally excite opsins with high spatial resolution.
Keywords :
"Brain","Mice","Neurons","Absorption","Glass","Microscopy","Nanocrystals"
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE
Electronic_ISBN :
1558-4615
DOI :
10.1109/EMBC.2015.7318488
