Title :
An ingestible, NIR-fluorometric, cancer-screening capsule
Author :
Panayiota Demosthenous;Julius Georgiou
Author_Institution :
Holistic Electronics Research Lab of the Department of Electrical and Computer Engineering, University of Cyprus, 1678 Nicosia, Cyprus
Abstract :
Asymptomatic, early-stage, cancer detection is a problem in the small intestine, that is largely inaccessible. This paper presents a cost-effective screening capsule prototype, which is able to detect infrared (IR) fluorescence emitted by indocyanine green (ICG) fluorophore dye. The presented mixed-signal system has a small size, consumes little power and works as a high-sensitivity fluorometer that records fluorescence levels throughout the small intestine, rather than collecting images that need labour intensive video analysis. Ex-vivo experiments, on ICG-impregnated swine intestine, have shown that the prototype system is able to detect low concentrations of ICG in the nanomolar and micromolar region, which is required to detect early cancer in the small intestine.
Keywords :
"Intestines","Cancer","Endoscopes","Yttrium","Prototypes","Imaging","Photodiodes"
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE
Electronic_ISBN :
1558-4615
DOI :
10.1109/EMBC.2015.7318813