Correlation of clinical parameters with cardiorespiratory behavior in successfully extubated extremely preterm infants

Extremely preterm infants (gestational age ≤ 28 weeks) often require EndoTracheal Tube-Invasive Mechanical Ventilation (ETT-IMV) to survive. Clinicians wean infants off ETT-IMV as early as possible using their judgment and clinical information. However, assessment of extubation readiness is not accurate since 20 to 40% of preterm infants fail extubation. We extended our work in automated prediction of extubation readiness by examining correlations of automated cardiorespiratory features to clinical parameters in successfully extubated infants. Only a few features, mainly those related to variability of breathing synchrony, had any consistent correlation with clinical parameters, namely gestational age, day of life at extubation, and bicarbonate. We conclude that the automated cardiorespiratory features likely provide different information additional to clinical practice.