Spectral decomposition of pupillary unrest using wavelet entropy

Respiratory and cardiovascular rhythms were discovered in the temporal fluctuations of pupil sizes. The mechanism is physiologically explainable but the potential clinical importance of pupillary unrest has not been studied extensively in the past. Here we analyzed the pupillograms of 29 healthy controls on different time scales and correlated the results to established indices of cardiovascular and cardiorespiratory autonomic function. We discovered a clear lateralization of pupil unrest dependencies. Correlation to vagal heart rate regulation and baroreflex sensitivity indicates the significance of the left pupil´s fluctuations evaluating the status of the autonomic nervous system.