Title :
On the roles of vascular smooth muscle contraction in cerebral blood flow autoregulation - a modeling perspective
Author :
Jin Yang;John W. Clark
Author_Institution :
CAS-MPG Partner Institute of Computational Biology, Shanghai Institutes for Biological Sciences, China 200031
Abstract :
We here review existing models of vascular smooth muscle cell, endothelial cell and cell-cell communication, which have been developed to better understand vascular tone and blood flow autoregulation. In particular, we discuss models that intended to explain modulation of myogenic tone by intraluminal pressure in resistance arterioles. Modeling efforts in the recent past have witnessed a shift from empirical models to models with mechanistic details that underscore different physical aspects of vascular regulation. Future models should synthesize mechanistic interactions in a hierarchy, from molecular regulation of ion channels to whole organ blood flow control.
Keywords :
"Mathematical model","Biological system modeling","Muscles","Couplings","Arteries","Stress","Biomembranes"
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE
Electronic_ISBN :
1558-4615
DOI :
10.1109/EMBC.2015.7320200