Title :
Urea and guanidinium chloride act as ‘water structure breakers’: The debate revisited by dielectric relaxation study in THz range
Author :
Nirnay Samanta;Debasish Das Mahanta;Rajib Kumar Mitra
Author_Institution :
Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block-JD, Sector-III, Salt Lake, Kolkata 700098, India
Abstract :
We have addressed a very fundamental question, whether urea and guanidinium chloride (GdmCl) act as water `structure breakers´. Our study using THz time domain spectroscopy (TTDS) confirm that both these molecules perturb the extended solvation layer around themselves which supports the strongly debated “water structure breaker” notion of urea and GdmCl during their protein denaturation process[1,2].
Keywords :
"Proteins","Hydrogen","Sugar","Absorption","Dielectric constant","Acceleration"
Conference_Titel :
Infrared, Millimeter, and Terahertz waves (IRMMW-THz), 2015 40th International Conference on
Electronic_ISBN :
2162-2035
DOI :
10.1109/IRMMW-THz.2015.7327766
