• DocumentCode
    3691550
  • Title

    Urea and guanidinium chloride act as ‘water structure breakers’: The debate revisited by dielectric relaxation study in THz range

  • Author

    Nirnay Samanta;Debasish Das Mahanta;Rajib Kumar Mitra

  • Author_Institution
    Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block-JD, Sector-III, Salt Lake, Kolkata 700098, India
  • fYear
    2015
  • Firstpage
    1
  • Lastpage
    2
  • Abstract
    We have addressed a very fundamental question, whether urea and guanidinium chloride (GdmCl) act as water `structure breakers´. Our study using THz time domain spectroscopy (TTDS) confirm that both these molecules perturb the extended solvation layer around themselves which supports the strongly debated “water structure breaker” notion of urea and GdmCl during their protein denaturation process[1,2].
  • Keywords
    "Proteins","Hydrogen","Sugar","Absorption","Dielectric constant","Acceleration"
  • Publisher
    ieee
  • Conference_Titel
    Infrared, Millimeter, and Terahertz waves (IRMMW-THz), 2015 40th International Conference on
  • ISSN
    2162-2027
  • Electronic_ISBN
    2162-2035
  • Type

    conf

  • DOI
    10.1109/IRMMW-THz.2015.7327766
  • Filename
    7327766
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3691550