The evaluation system for measuring sensitivity of microbubbles to target molecules using a quartz crystal microbalance

Targeted microbubbles (MBs) has been applied to the ultrasound molecular imaging. It is important to understand the sensitivity of bubbles to the target molecules. Thus, we aim to construct an evaluation system using quartz crystal microbalance (QCM) to measure quantitatively both the concentration of target molecular and the number density of specifically-absorbed MBs. To quantitatively counting absorbed MBs on QCM, the physical model for expressing the relationship between the impedance of QCM and absorbed MBs was proposed in our previous study. In this paper, we validates the model based on the comparison of model-based analysis of the number density of MBs with the value measured by using an optical microscope.