A 3 MHz/18 MHz dual-layer co-linear array for transrectal acoustic angiography

In this paper, a novel dual layer co-linear array ultrasound transducer was developed for transrectal dual-frequency superharmonic imaging. The KLM model and Field II were used for the acoustic stack design and simulation of the acoustic field of the array, respectively. The newly designed and fabricated probe consists of 50 transmit elements with a center frequency of 3 MHz and 100 receive elements with a center frequency of 18 MHz. The dimensions of the array are 15 mm in azimuth and 9 mm in elevation. The pitch is 270 μm for the transmitting elements and 135 μm for the receiving element. Pulse-echo testing of TX/RX elements corresponded with the simulation results. Real-time contrast imaging was tested using a multi-channel imaging system. The non-linear responses from microbubble contrast agents flowing through a 200 μm cellulose tube at a distance of 30 mm from the probe were clearly observed and displayed in the image. The axial beam width and CNR were calculated to be 200 μm and 18 dB, respectively. These results suggest that the prototyped co-linear array is capable of performing dual-frequency superharmonic imaging of microbubbles (“acoustic angiography”) for prostate cancer assessment.