Multiple model SPGPC for blood pressure control

Multiple model adaptive control procedures have been considered for a computer-based feedback system, which regulates the infusion rate of a drug (nitroprusside) in order to maintain the blood pressure as close as possible to the desirable value. Transfer function parameters can differ significantly between patients, and also time-dependent, so the development of a suitable algorithm becomes required not only for maintaining steady-state but also the transient specifications. In this paper, based on computer simulations, a multiple model adaptive control procedures show to be successfully applied to blood pressure control, despite the uncertainty related with delays, time constant and gains associated.