Deep neural network based protein-protein interaction extraction from biomedical literature

This paper presents a deep neural network-based protein-protein interactions (PPIs) information extraction approach which can learn complex and abstract features automatically from unlabeled data by unsupervised representation learning methods. This approach first employs the training algorithm of auto-encoders to initialize the parameters of a deep multilayer neural network. Then the gradient descent method using back-propagation is applied to train this deep multilayer neural network model. Experimental results on five public PPI corpora show that our method can achieve better performance than can a multilayer neural network. In addition, the performance comparison with APG also verifies the effectiveness of our method.