• DocumentCode
    3734804
  • Title

    Delivery system for AZT-triphosphate analogues based on SiO2 nanoparticles

  • Author

    Svetlana V. Vasilyeva;Vladimir N. Silnikov;Natalia V. Shatskaya;Asya S. Levina;Nikolai S. Li-Zhulanov;Natalia A. Mazurkova;Kasivelu Govindaraju

  • Author_Institution
    Siberian Branch of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
  • fYear
    2015
  • fDate
    7/1/2015 12:00:00 AM
  • Firstpage
    1054
  • Lastpage
    1057
  • Abstract
    SiO2 nanoparticles as platform for delivery of 3´-triazole analogues of AZT-triphosphate into cells were proposed. The results confirmed the successfulness of the Huisgen´s 1,3-dipolar cycloaddition reaction for the preparation of the SiO2~dNTP nanocomposites. It was shown that polymerase can recognize nucleoside triphosphates in the proposed nanobiocomposites and incorporate them into the growing DNA chain. The proposed SiO2~dNTP nanocomposites were demonstrated to penetrate into eukaryotic cells. The tentative results indicate that these nanocomposites at low concentrations can inhibit the reproduction of POX and Herpes viruses. This makes it possible to use the nanobiocomposites bearing nucleoside triphosphate analogues as promising therapeutic drugs.
  • Keywords
    "Nanoparticles","Nanocomposites","DNA","Polymers","Viruses (medical)","Substrates","Chemistry"
  • Publisher
    ieee
  • Conference_Titel
    Nanotechnology (IEEE-NANO) , 2015 IEEE 15th International Conference on
  • Type

    conf

  • DOI
    10.1109/NANO.2015.7388802
  • Filename
    7388802
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3734804