Title :
Rate-adapted dynamic-clamp of the funny current in sinoatrial pacemaker cells
Author :
Chiara Bartolucci;Enrico Ravagli;Annalisa Bucchi;Mirko Baruscotti;Dario DiFrancesco;Stefano Severi
Author_Institution :
Department of Electrical, Electronic and Information Engineering, University of Bologna, Italy
Abstract :
A typical feature of sinoatrial node (SAN) pacemaker cells is the presence of an ionic current, named `funny current´, If, that activates upon hyperpolarization. We aimed to: 1) test the impact of different mathematical models of If (Maltsev-Lakatta and Severi-DiFrancesco) in real cells by using the Dynamic Clamp (DC) technique; 2) adapt the DC protocol to adequately simulate a shift of the If activation curve.
Keywords :
"Protocols","Heart","Rabbits","Electric potential","Kinetic theory","TV","Adaptation models"
Conference_Titel :
Computing in Cardiology Conference (CinC), 2015
Print_ISBN :
978-1-5090-0685-4
Electronic_ISBN :
2325-887X
DOI :
10.1109/CIC.2015.7408571
