DocumentCode :
374778
Title :
Optimization and evaluation of reconstruction-based compensation methods in myocardial perfusion SPECT using the channelized Hotelling observer
Author :
Frey, E.C. ; La Croix, K.J. ; Tsui, Benjamin M. W.
Author_Institution :
Dept. of Biomed. Eng., North Carolina Univ., Chapel Hill, NC, USA
Volume :
2
fYear :
2000
fDate :
2000
Abstract :
Summary form only given. We have applied the channelized Hotelling observer (CHO) using a defect detection task to the optimization and evaluation of iterative reconstruction compensation for myocardial perfusion SPECT. We used a population of 24 mathematical cardiac-torso (MCAT) phantoms that realistically model the activity and attenuation distribution in three classes of patients: females and males with flat and raised diaphragms. Defects were placed at 6 positions along myocardium. Projection data were generated and subsequently reconstructed using methods based on the ordered-subsets expectation-maximization algorithm. The methods evaluated included iterative reconstruction compensation for attenuation, detector response blurring and scatter in various combinations. We applied the CHO to find the optimal number of iterations and cutoff frequency of a post-reconstruction filter that gave the highest value of the area under the receiver operating characteristics (ROC) curve (AUC). We investigated from 1 to 12 iterations with 16 subsets per iteration and an order 8 Butterworth post-reconstruction filter with cutoff frequencies of 0.04 to 0.34 pixel-1. For the optimal reconstruction parameters, attenuation with either detector response or scatter compensation gave statistically significant increases in the AUC compared to attenuation compensation alone. The greatest increase in the AUC occurred when all three compensations were applied
Keywords :
cardiology; haemorheology; image reconstruction; image segmentation; iterative methods; maximum likelihood estimation; medical image processing; observers; single photon emission computed tomography; area under ROC curve; attenuation distribution; cardiac-torso phantoms; channelized Hotelling observer; cutoff frequency; detector response blurring; iterative reconstruction compensation; myocardial perfusion SPECT; optimal number of iterations; optimization; ordered-subsets EM algorithm; post-reconstruction filter; reconstruction-based compensation methods; scatter compensation; Attenuation; Cutoff frequency; Detectors; Expectation-maximization algorithms; Filters; Imaging phantoms; Iterative methods; Mathematical model; Myocardium; Scattering;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium Conference Record, 2000 IEEE
Conference_Location :
Lyon
ISSN :
1082-3654
Print_ISBN :
0-7803-6503-8
Type :
conf
DOI :
10.1109/NSSMIC.2000.949988
Filename :
949988
Link To Document :
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