• DocumentCode
    3749062
  • Title

    Evaluating exponential integrators for Markov chain ion channel models

  • Author

    Tom?? Star?;Vadim N. Biktashev

  • Author_Institution
    CEMPS, University of Exeter, UK
  • fYear
    2015
  • Firstpage
    885
  • Lastpage
    888
  • Abstract
    We evaluate the accuracy and efficiency of an exponential integrator method applied to a cardiac excitation model with numerically stiff Markov chain (MC) description of ionic channels, namely Ryanodine receptor (RyR) and L-type calcium channel ICa(L). If solved by explicit methods such as forward Euler (FE), the stability constraints for these MC models require very small time steps.
  • Keywords
    "Iron","Markov processes","Numerical models","Logic gates","Computational modeling","Mathematical model","Calcium"
  • Publisher
    ieee
  • Conference_Titel
    Computing in Cardiology Conference (CinC), 2015
  • ISSN
    2325-8861
  • Print_ISBN
    978-1-5090-0685-4
  • Electronic_ISBN
    2325-887X
  • Type

    conf

  • DOI
    10.1109/CIC.2015.7411053
  • Filename
    7411053
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3749062