DocumentCode :
3758960
Title :
Sleep Deprivation Increased Dopamine D2 Receptor Expression through Downregulation of miR-9
Author :
Ruojian Wen;Xiaoqing Chen;Dan Huang;Minjie Chen;Yuwei Liu
Author_Institution :
Found. Dept., Jianghan Univ., Wuhan, China
fYear :
2015
Firstpage :
239
Lastpage :
242
Abstract :
Sleep-wake cycle is a complex process relates to a variety of neurotransmitters and receptors in the central nervous system (CNS), also involves a large number of gene transcription and translation. MicroRNAs (miRNAs) have emerged as important regulators of gene expression, which mediate translational repression and/or mRNA decay of a target gene. Dopamine D2 receptor (DRD2) gene is predicted as a target gene of a brain-enriched miRNA, miR-9, but their functions in sleep-wake cycle remain unknown. In this study, we reported that REM sleep deprivation decreases the level of miR-9 and this induction is associated with the expression of DRD2 proteins. Thus, miR-9 may control DRD2 gene translation in the prefrontal cortex for processing sleep deprivation. Our findings may have implications in understanding the biological relevance of the genetic associations of sleep disorders. Furthermore, miR-9 may be considered as potential drug targets for the treatment of disorders involving abnormal DRD2 function, such as insomnia.
Keywords :
"Rats","Sleep","Proteins","Gene expression","RNA","Neurotransmitters","Databases"
Publisher :
ieee
Conference_Titel :
Information Technology in Medicine and Education (ITME), 2015 7th International Conference on
Type :
conf
DOI :
10.1109/ITME.2015.122
Filename :
7429137
Link To Document :
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