Title :
Inducing blood vessel formation using cubic eggshell with patterned surface
Author :
Wenjing Huang;Fumihito Arai;Tomohiro Kawahara
Author_Institution :
Department of Biological Functions Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, 808-0196, Japan
Abstract :
We have developed a cubic eggshell made of a cubic polycarbonate frame and 6 PDMS membranes. Development of embryo circulatory system was observed on the transparent side membrane. We hypothesized that blood vessels, which adhered on the side membrane for oxygen absorption, respond specifically to different oxygenated environment. To test this hypothesis, we designed patterned surfaces with selective oxygen permeation areas, and found that blood vessels formed selectively in oxygenated channels, which suggested a novel method for the control of blood vessel formation.
Keywords :
"Biomembranes","Computer aided manufacturing","Blood vessels","Embryo"
Conference_Titel :
Micro-NanoMechatronics and Human Science (MHS), 2015 International Symposium on
DOI :
10.1109/MHS.2015.7438255
