Observation of the permeation on the subcutaneous during the administration of drug and design of a needle

In recent years, the number of diabetics in Japan is increasing every year. Diabetics need to perform insulin administration for treatment. Compared with other methods in the injection method into the subcutaneous tissue, the hypodermic injection which the effect of a medicine maintains is used in that case. However, there are few study cases about the percolation process of the medicine at the time of a hypodermic injection, design of the needle in consideration of the efficiency of drug penetration as well as durability despite being sought, the design of the hypodermic needle for medication which a medicine is made to permeate efficiently is not yet made. Therefore, confirmation of subcutaneous infiltration process has become an issue. In this study, it is an object of the present invention to confirm the impact of differences due to penetration trend of the shape of the needle intratubular. The confirmation of penetration tendency subcutaneous with straight needle and double tapered needle used during administration of insulin was conducted. The permeation area after injection was confirmed using a eutectic point laser microscope for measurement. The fluorescent labeling reagent was observed of the penetration process of when administered to back of nude mice. A result of the penetration area comparison, the reagents in double taper needle it was confirmed tendency to widely penetrate.