Label-free detection of DNA hybridization on MoS2 using photoluminescence measurements

We have fabricated a 2d-materials heterostructure (graphene/MoS₂) for label-free selective detection of DNA hybridization. The graphene protected the MoS₂ from ambient moisture and oxygen and acted as a biocompatible host for the DNA molecules. The photoluminescence intensity from the MoS₂ layer increased with increased concentration of target DNA. The differentiation of complementary and one-base mismatched DNA with the 2d-materials heterostructure could be performed at a concentration as low as 1 attomole (10-18 M).