Artificial neural network applications in immunology

Artificial neural network (ANN) applications in immunology include simulations of peptide binding to histocompatibility complex molecules, which present peptides for recognition by the immune system. These peptides are derived from protein antigens and represent prime targets for vaccine discovery. ANN models have proven superior when compared to the alternative models. Applications of ANN models help minimise the number of necessary wet-lab experiments. In this article we describe three specific applications in which targets of immune recognition have been determined from diabetes-, melanoma-, and malaria-related antigens.