DocumentCode :
378692
Title :
Monte Carlo simulation of ultrasound backscattering by aggregating red blood cells
Author :
Savéry, David ; Cloutier, Guy
Author_Institution :
Lab. of Biorheology & Med. Ultrasonics, Univ. of Montreal Hosp., Que., Canada
Volume :
2
fYear :
2001
fDate :
2001
Firstpage :
1229
Abstract :
When blood flows at a low shear rate, red cells aggregate and form clusters that affect vascular resistance to flow and blood echogenicity. This study intends to clarify the relation between the red cell aggregation level and the ultrasonic backscatter increase. Red cell positioning in plasma is modeled by a 2D Markov point process at a 40% hematocrit. A square well potential is adopted to take into account the erythrocyte adhesive interaction energy. Monte Carlo simulations of the point process and computations of the mean structure factor enables to assess the frequency dependence of the blood backscatter for different aggregation potentials. The ultrasonic sensitivity to the erythrocyte clustering phenomenon is demonstrated and could be used as a noninvasive measurement method of blood microstructure and rheology
Keywords :
Monte Carlo methods; aggregation; backscatter; biomedical ultrasonics; blood; cellular transport; haemorheology; ultrasonic scattering; 2D Markov point process; Metropolis method; Monte Carlo simulation; aggregating red blood cells; blood echogenicity; blood rheology; effective aggregation potential; ensemble average; erythrocyte adhesive interaction energy; erythrocyte clustering; frequency dependence; low shear rate; mean structure factor; noninvasive measurement method; packing conformation; red cell clusters; square well potential; ultrasonic sensitivity; ultrasound backscattering; vascular resistance; Aggregates; Backscatter; Blood flow; Cells (biology); Frequency dependence; Microstructure; Noninvasive treatment; Plasma simulation; Potential well; Ultrasonic imaging;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium, 2001 IEEE
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-7177-1
Type :
conf
DOI :
10.1109/ULTSYM.2001.991941
Filename :
991941
Link To Document :
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