Intra and intersubject registration in multimodal brain imaging utility for source analysis

MOBIUS (Multimodal Brain Imaging Utility for Source Analysis) is a system developed for interactively processing brain related data. The system aims at facilitating visual inspection of both anatomical (e.g. MRI) and functional (e.g. PET, EEG, ERP) brain data by registration, analyzing electrical sources by numerically solving inverse problems, and quantitatively comparing brain activities by geometric mapping. For quantitative analyses of inter-subject and intra-subject modalities, robust algorithms are employed for registration in MOBIUS including automatic intrasubject MRI-PET registration and landmark-based intersubject MRI-registration methods. Modifications and improvements to existing registration methods are presented, along with implications of the methods for multimodal study.