Title :
A novel microdialysis glucose sensor system based on co-immobilizing on Au micro-electrode by sol-gel technique
Author :
Yu, Ping ; Liu, Weiting ; Chen, Yuquan ; Li, Guang
Author_Institution :
Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou, China
Abstract :
A microdialysis sensor system for continuous glucose measurements has been developed. The sensor is based on co-immobilizing glucose oxidase (GOD) with the catalase by a sol-gel technique on the surface of silicon bases with two pattern of Au microelectrodes. A graduated ("sandwich") immobilizing method is performed to improve the stability and the lifetime of the co-enzyme system. The response of the system was in good order. Above all, we developed a new geometry of the bispiral microelectrode with numerical analysis of its electrochemical character.
Keywords :
biomedical electrodes; biomedical transducers; biosensors; electrochemical electrodes; electrochemical sensors; microelectrodes; organic compounds; patient monitoring; sol-gel processing; Au; Au micro-electrode; Au microelectrodes; Si; bispiral microelectrode; catalase; coenzyme system lifetime; continuous glucose measurements; continuous glucose monitoring; diabetes clinical management; electroanalytcal chemistry; electrochemical character; glucose oxidase co-immobilization; graduated immobilizing method; microdialysis glucose sensor system; numerical analysis; sandwich immobilizing method; silicon surface; sol-gel technique; stability; Biomedical measurements; Biosensors; Electrodes; Gold; Insulation; Microelectrodes; Monitoring; Sensor systems; Stability; Sugar;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1017454
