Title :
Cell-specific ionic models of cardiac pacemaker activity
Author :
Dokos, S. ; Cloherty, S.L. ; Lovell, N.H. ; Zaza, A.
Author_Institution :
Graduate Sch. of Biomed. Eng., New South Wales Univ., Sydney, NSW, Australia
Abstract :
We have developed a generic ionic model of single-cell rabbit sinoatrial node (SAN) electrical activity, employing Markov-state kinetics for membrane ionic currents. By suitable choice of parameters, the model is able to accurately reproduce a wide range of action potential waveforms recorded from individual SAN cells in the laboratory. Advantages of this approach include the ability to quantitatively investigate the contribution of ion currents underlying pacemaker and action potential activity from any given SAN myocyte recording.
Keywords :
bioelectric potentials; biomembrane transport; cardiology; neurophysiology; physiological models; Markov-state kinetics; action potential activity; action potential waveforms reproduction; cardiac electrophysiology; generic ionic model; mathematical model; membrane ionic currents; single-cell rabbit sinoatrial node electrical activity; Biomedical engineering; Biomembranes; Biotechnology; Cells (biology); Kinetic theory; Laboratories; Mathematical model; Pacemakers; Rabbits; Storage area networks;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1018832
