Effect of calcium-activated chloride current blockade on the delayed after depolarizations. Simulation study

Author

Gomis-Tena, J. ; Saiz, J.

Author_Institution

Laboratorio Integrado de Bioingenieria, Univ. Politecnica de Valencia, Spain

Volume

1

fYear

2001

fDate

2001

Firstpage

19

Abstract

High intracellular calcium conditions cause a calcium-activated transient inward current (I_ti) that can provoke oscillations in membrane potential called delayed after depolarizations (DAD). The current I_ti comprises of the sodium-calcium exchange current (I_NaCa) and the calcium-activated chloride current (I_NaCa). Lindblad, Murphey, Clark and Giles (1996) developed a mathematical model (LMCG model) of the rabbit atrial AP. In this study, a modified AP LMCG model that includes I_Cl-Ca. is used to evaluate the contribution of I_Cl-Ca to develop DADs. Our results suggest that although I_Na-Ca is the main component of I_ti (65%), I_Cl-Ca may play a significant role in DAD generation. Even more, the I_Cl-Ca blockade could inhibit the DAD propagation and trigger activity associated to high [Ca²⁺]_i condition, in atrial tissue.

Keywords

bioelectric phenomena; biomembrane transport; calcium; cardiology; physiological models; Ca; Na; atrial tissue; calcium-activated chloride current blockade; calcium-activated transient inward current; cardiac electrophysiology; delayed after depolarizations; mathematical model; membrane potential oscillations; simulation study; sodium-calcium exchange current; Biomembranes; Calcium; Delay effects; Gears; Induction generators; Laboratories; Mathematical model; Nonlinear equations; Rabbits; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1018833

Filename

1018833