DocumentCode :
380395
Title :
A noninvasive method for characterizing ventricular diastolic filling dynamics
Author :
Mukkamala, R. ; Mark, R.G. ; Cohen, R.J.
Author_Institution :
Harvard-MIT Div. of Health Sci. & Technol., Cambridge, MA, USA
Volume :
1
fYear :
2001
fDate :
2001
Firstpage :
147
Abstract :
We developed a novel method for estimating a single parameter (τD) which summarizes the diastolic filling dynamics of the ventricle that governs the effects of diastolic filling time on stroke volume. The method involves the analysis of beat-to-beat fluctuations in heart rate, arterial blood pressure, and left ventricular stroke volume, each of which may be measured noninvasively in humans. In order to evaluate the method, we constructed a computational model of the human cardiovascular system. We applied the method to data generated from the computational model and found close agreement between the estimated and actual τD. We also demonstrated with computational model examples that the method could be utilized to monitor increasing degrees of cardiac tamponade and mitral stenosis, two cardiovascular disease processes which prohibit the ventricles from filling adequately. This model-based study motivates the experimental validation of the method.
Keywords :
cardiovascular system; haemodynamics; identification; physiological models; arterial blood pressure; beat-to-beat fluctuations; cardiac tamponade; cardiovascular disease processes; computational model; experimental validation; heart rate; left ventricular stroke volume; mitral stenosis; model-based study; noninvasive method; stroke volume; ventricular diastolic compliance; ventricular diastolic filling dynamics characterization; Anthropometry; Arterial blood pressure; Computational modeling; Filling; Fluctuations; Heart rate; Humans; Parameter estimation; Pressure measurement; Volume measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
ISSN :
1094-687X
Print_ISBN :
0-7803-7211-5
Type :
conf
DOI :
10.1109/IEMBS.2001.1018872
Filename :
1018872
Link To Document :
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