Title :
Transient changes of vascular smooth muscle tone and myogenic response to acute hypertension
Author :
Makino, Akihiro ; Miyazaki, H. ; Hayashi, K. ; Stergiopulos, Nikolaos
Abstract :
Summary form only given. We studied the biomechanical adaptation of the rat common carotid artery to acute hypertension. Hypertension was induced by aortic banding. Measurements were performed 2, 4, 8 and 56 days after surgery. Pressure increased from 92±2 mm Hg to 148±1 mm Hg. Hypertension leads to an 18% thickness increase within 8 days. The vascular smooth muscle increased significantly its basal tone as well as its myogenic tone within the first period following the induction hypertension, but in the long-term tone returned to control levels. A biomechanical model has been elaborated to describe the evolution of this transient changes in vascular tone.
Keywords :
biomechanics; blood vessels; haemodynamics; muscle; 148 mmHg; 2 to 56 d; 92 mmHg; acute hypertension; aortic banding; arterial remodeling; basal tone; biomechanical adaptation; myogenic response; rat carotid; transient changes; vascular smooth muscle tone; Carotid arteries; Hypertension; Muscles; Performance evaluation; Surgery;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1018886