A cellular based model of the myogenic response in isolated rat cerebral arteries

Author

Yang, J. ; Clark, J.W. ; Bryan, R. ; Robertson, C.

Author_Institution

Bioeng. Dept., Rice Univ., Houston, TX, USA

Volume

1

fYear

2001

fDate

2001

Firstpage

244

Abstract

This study is concerned with the development of an integrated multiple compartment model of the isolated cerebral artery in the rat. The smooth muscle/arterial wall complex is an important component of the circulatory model and serves as an "vasomotor organ", which provides the myogenic mechanism. We have focused on this myogenic mechanism and have developed a model of the electrophysiological, contractile and mechanical characteristics of the single smooth muscle cell. This cell model is used to interrelate the topics of arterial wall stress, changes in transmembrane potential, intracellular [Ca²⁺]_i concentration and smooth muscle contraction. Moreover, the small cell model is embedded in a larger arterial wall model, which converts contractile activity into changes in lumen diameter. The complete model is used to provide biophysically based explanations of the myogenic mechanisms underlying the autoregulation of cerebral blood flow.

Keywords

biocontrol; bioelectric potentials; biomechanics; biomembrane transport; blood vessels; brain models; haemorheology; muscle; Ca²⁺; arterial wall stress; biophysically based explanations; cellular based model; cerebral blood flow autoregulation; circulatory model; contractile activity; contractile characteristics; electrophysiological characteristics; integrated multiple compartment model; intracellular Ca²⁺ concentration; isolated cerebral artery; isolated rat cerebral arteries; larger arterial wall model; lumen diameter changes; mechanical characteristics; microcirculation; myogenic response; single smooth muscle cell; small cell model; smooth muscle contraction; smooth muscle/arterial wall complex; transmembrane potential; vasomotor organ; Arteries; Biomedical engineering; Biomembranes; Blood flow; Cells (biology); Educational institutions; Equivalent circuits; Muscles; Neurosurgery; Stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1018901

Filename

1018901