An integrated model of the human cardiopulmonary system

Author

Lu, K. ; Clark, J.W. ; Ghorbe, F.H. ; Ware, D.L. ; Bidan, A.

Author_Institution

Dynamical Syst. Group, Rice Univ., Houston, TX, USA

Volume

1

fYear

2001

fDate

2001

Firstpage

412

Abstract

We have developed a mathematical model of the human cardiopulmonary system that is able to simulate the normal functions of the cardiovascular and pulmonary systems, as well as their coupled interactions. Included in the model are descriptions of atrial and ventricular mechanics, the hemodynamics of the systemic and pulmonic circulations, baroreflex control of arterial pressure, airway and lung mechanics, as well as, gas transport at alveolar-capillary membrane. With the suitable parameter set, the integrated cardiopulmonary model yielded pressure, volume and flow waveforms that agree well with published data. In addition, The model demonstrated stability under large amplitude perturbations of the physiological variables, such as Valsalva Maneuver.

Keywords

biocontrol; biomembrane transport; cardiovascular system; haemodynamics; physiological models; pneumodynamics; pressure control; Valsalva Maneuver; airway mechanics; alveolar-capillary membrane; baroreflex control; cardiopulmonary disease; cardiopulmonary modeling; closed-loop hemodynamics; gas exchange; gas transport; human cardiopulmonary system; integrated model; large amplitude perturbations; lung mechanics; mathematical model; physiological variables; ventricular interaction; Baroreflex; Biomembranes; Blood pressure; Cardiology; Hemodynamics; Humans; Lungs; Mathematical model; Pressure control; Stability;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1018949

Filename

1018949