Title :
An integrated model of the human cardiopulmonary system
Author :
Lu, K. ; Clark, J.W. ; Ghorbe, F.H. ; Ware, D.L. ; Bidan, A.
Author_Institution :
Dynamical Syst. Group, Rice Univ., Houston, TX, USA
Abstract :
We have developed a mathematical model of the human cardiopulmonary system that is able to simulate the normal functions of the cardiovascular and pulmonary systems, as well as their coupled interactions. Included in the model are descriptions of atrial and ventricular mechanics, the hemodynamics of the systemic and pulmonic circulations, baroreflex control of arterial pressure, airway and lung mechanics, as well as, gas transport at alveolar-capillary membrane. With the suitable parameter set, the integrated cardiopulmonary model yielded pressure, volume and flow waveforms that agree well with published data. In addition, The model demonstrated stability under large amplitude perturbations of the physiological variables, such as Valsalva Maneuver.
Keywords :
biocontrol; biomembrane transport; cardiovascular system; haemodynamics; physiological models; pneumodynamics; pressure control; Valsalva Maneuver; airway mechanics; alveolar-capillary membrane; baroreflex control; cardiopulmonary disease; cardiopulmonary modeling; closed-loop hemodynamics; gas exchange; gas transport; human cardiopulmonary system; integrated model; large amplitude perturbations; lung mechanics; mathematical model; physiological variables; ventricular interaction; Baroreflex; Biomembranes; Blood pressure; Cardiology; Hemodynamics; Humans; Lungs; Mathematical model; Pressure control; Stability;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1018949
