Title :
Investigation of blood proteins adsorption on coated and uncoated hollow fiber surfaces in extracorporeal circuits during cardiopulmonary bypass
Author :
Kocakulak, M. ; Gunaydin, S. ; Saber, R. ; Kocum, Cengiz ; Farsak, B. ; Bingol, N. ; Sari, T. ; Yorgancioglu, C. ; Zorlutuna, Y. ; Ayhan, Hayriye ; Piskin, E.
Author_Institution :
Chem. Eng. Dept., Hacettepe Univ., Ankara, Turkey
Abstract :
Poly(2-methoxyethylacrylate)-PMEA theoretically reduces protein and platelet adsorption. 55 patients undergoing three-vessel coronary artery bypass were operated with PMEA coated and uncoated extracorporeal circuits. Contrary to coated circuits, it is observed that more protein adhesion occurs on uncoated fiber surfaces. As a clinical observation, less bleeding was observed for coated system.
Keywords :
adhesion; adsorption; blood; cardiovascular system; coagulation; proteins; surgery; Xcoating model oxygenator; aggregation; amphiphilic organic polymer; blood proteins adsorption; cardiopulmonary bypass; coated hollow fiber surfaces; extracorporeal circuits; poly(2-methoxyethylacrylate) coating; postoperative hemorrhage; protein adhesion; protein desorption; three-vessel coronary artery bypass; uncoated hollow fiber surfaces; Adhesives; Arteries; Biomedical engineering; Blood; Cardiology; Chemical engineering; Circuits; Polymer films; Proteins; Surgery;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1018963
