Title :
Neurogenesis of respiratory rhythm: a computational study
Author :
Rybak, I.A. ; Paton, J.F.R. ; -John, W. M St
Author_Institution :
Sch. of Biomed. Eng., Drexel Univ., Philadelphia, PA, USA
Abstract :
Results of computational modeling of the respiratory rhythm generation have been used for analysis of the conditions that may define a network-based vs. a pacemaker-driven rhythm-generating mechanism. The possible cellular and network factors contributing to the transitions between the network-based and pacemaker-driven oscillations are discussed in connection with experimental data obtained its vivo, in situ and in vitro.
Keywords :
biomembrane transport; brain models; neural nets; neurophysiology; pneumodynamics; brainstem; cellular factors; computational study; experimental data; functionally different populations; gasping; inhibitory interactions; ionic channels; network factors; pacemaker-driven oscillations; pacemaker-driven rhythm-generating mechanism; respiratory neurons; respiratory rhythm neurogenesis; Biomedical computing; Cellular networks; Computational modeling; Computer networks; In vitro; In vivo; Neurons; Pacemakers; Physiology; Rhythm;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1019064
