Title :
High throughput challenges in molecular cell biology: the CELL MAP
Author :
Bergeron, John J.M. ; Desjardins, Miche ; Thomas, David Y. ; Kearney, Robert E.
Author_Institution :
McGill Univ., Montreal, Que., Canada
Abstract :
Summary form only given. The complete elucidation of the protein complement of all compartments of the eukaryotic cell is under way. This poses logistical problems in sample preparation and high throughput but exhaustive characterization. Using examples of protein characterization of organelles by mass spectrometry and the validation of protein function by DNA chips, the engineering and bioinformatics challenges in proteomics and genomics are illustrated.
Keywords :
DNA; biocybernetics; biological specimen preparation; cellular biophysics; genetics; mass spectroscopic chemical analysis; molecular biophysics; proteins; CELL MAP; DNA chips; bioinformatics challenges; engineering challenges; eukaryotic cell compartments; exhaustive characterization; genomics; high throughput challenges; logistical problems; mass spectrometry; molecular cell biology; organelles; protein characterization; protein complement; protein function; proteomics; sample preparation; Bioinformatics; Biological cells; DNA; Genomics; Mass spectroscopy; Protein engineering; Proteomics; Throughput;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1019745
