Monitoring of Tumor Response to Au Nanorod-Indocyanine Green Conjugates Mediated Therapy With Fluorescence Imaging and Positron Emission Tomography

Author

Fei Liu ; Yue Zhang ; Shuangquan Liu ; Bin Zhang ; Qing Liu ; Yi Yang ; Bin Zhang ; Jianwen Luo ; Baoci Shan ; Jing Bai

Author_Institution

Dept. of Biomed. Eng., Tsinghua Univ., Beijing, China

Volume

15

Issue

5

fYear

2013

fDate

Aug. 2013

Firstpage

1025

Lastpage

1030

Abstract

Fluorescence imaging can track the expression of fluorescent protein and ¹⁸F-fluorodeoxyglucose based positron emission tomography ( [¹⁸F]FDG-PET) can evaluate the changes of [¹⁸F]FDG uptake in tumor cells during the antitumor treatment. In this work, fluorescence imaging and [¹⁸F]FDG-PET were both employed to monitor tumor response to Au nanorod-indocyanine green (AuNR-ICG) conjugates mediated therapy in a subcutaneous MDA-MB-231 mouse xenograft model. Serial fluorescence and [¹⁸F]FDG-PET images following the antitumor treatment were obtained and quantitative analysis revealed significant decreases in fluorescence intensity and metabolic activity in tumors treated with AuNR-ICG conjugates under near infrared laser irradiation. The results suggest that the combination of fluorescence and [¹⁸F]FDG-PET imaging can provide a noninvasive tool to assess the tumor response to antitumor therapy on a molecular scale.

Keywords

biomedical optical imaging; cellular biophysics; fluorescence; gold; laser applications in medicine; molecular biophysics; nanomedicine; nanorods; photodynamic therapy; positron emission tomography; proteins; tumours; ¹⁸F-fluorodeoxyglucose based positron emission tomography; Au; [¹⁸F]FDG-PET; antitumor therapy; antitumor treatment; fluorescence imaging; fluorescence intensity; fluorescent protein; metabolic activity; molecular scale; nanorod-indocyanine green conjugates; near infrared laser irradiation; quantitative analysis; subcutaneous MDA-MB-231 mouse xenograft model; tumor cells; tumor response monitoring; Cancer; Fluorescence; Imaging; Medical treatment; Monitoring; Radiation effects; Tumors; $[^{18}{rm F}]$FDG-PET; Dual-modality imaging; fluorescence; photodynamic therapy; photothermal therapy;

fLanguage

English

Journal_Title

Multimedia, IEEE Transactions on

Publisher

ieee

ISSN

1520-9210

Type

jour

DOI

10.1109/TMM.2013.2244204

Filename

6425488